We are the Project Leader and Modeling & Simulation teams and drive the development of novel drugs forward with a lot of passion and commitment. We are the experts when it comes to assessing the pharmacokinetics, -dynamics, and nonclinical safety of drug candidates. Together with our colleagues, we like to go an extra mile, supporting projects from inception all the way to filing, but there is also space for fun and laughs in day-to-day life. We have an "us" culture and we balance our work with continuous personal growth and team development. Context: In the early phases of drug discovery, particularly in Lead Identification and Lead Optimization stages, modern computational methods can be of invaluable support to prioritize synthesis and testing of the most promising small molecule candidates to be then moved further along the value chain. A wide variety of computational models and techniques can be applied to virtual molecules prior to their synthesis to inform their profile across all the most critical domains, such as physico-chemical / DMPK properties, and toxicity endpoints. Compounds predicted to be the closest to the Target Compound Profile (TCP) will be prioritized for synthesis and in vitro profiling. Your tasks: The aim of this internship is to assess the impact of the systematic application of the most advanced computational models across domains to prioritize the synthesis of the most promising compounds (Small Moleculess) for the project(s) under investigation. Older, clinical-stage in house projects may be used to compare the compound(s) advanced at the time with those newly designed and selected with the new methodologies. Your Profile: You are passionate about drug development Your background is Pharmacy, Medicinal Chemistry, Computational Chemistry, or Data Sciences. You have a keen interest in data analysis, artificial intelligence, molecular modeling, PBPK modeling, drug design, drug-like properties, pharmacokinetics and toxicology. You are proficient in English and not afraid of interacting with colleagues in our Roche Innovation Center in Basel/Switzerland You are entrepreneurial and have a positive mindset and a can-do mentality! Your Benefits Your development is important to us: That's why we attach great importance to you being able to work on a variety of tasks and always learn something new. In order to support your development, you have regular exchanges and feedback with your internship supervisors. We are living in 2021: you can flexibly schedule your working hours and do home office. Of course, once the pandemic situation has improved, you have access to facilities and services at the Basel campus, such as the employee canteens, swimming pool, gym, and much more! Applications must include a CV, motivation letter and certificate of enrollment in one merged PDF document. Due to regulations non-EU/EFTA citizens must provide a certificate from the university stating that an internship is mandatory (“recommended” is not sufficient) as part of the application documents. More information about career start at Roche you can find here Tags: ROiQQ ROiLS ROiCH ROiPS ROiTEC ROiDaSc Job Level:Entry Level This employer is a corporate member of myGwork - LGBTQ+ professionals, the business community for LGBTQ+ professionals, students, inclusive employers & anyone who believes in workplace equality.