At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow. In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. This position is located in ADME, a chapter within global Pharmaceutical Sciences, where the fate of new chemical entities and biologics is a primary focus. The ADME Chapter works throughout all stages of compound development, from lead optimization to candidate selection, all clinical development phases to filing of new drug applications. We closely collaborate with our therapeutic areas and functions to convert hypotheses into innovative therapeutics. Job mission The Scientist in vitro ADME of biologics will design and execute the right experimental strategy to assess the disposition of new biologics drug R&D candidates across multiple disease areas. The main focus areas will be on tissue targeting, intracellular trafficking and target-mediated disposition processes assessed in complex cellular models. Your impact You set-up, validate and apply state-of-the art methodologies (e.g. complex cellular models, microphysiological systems, imaging) to assess receptor-mediated transport processes driving PK/PD relationships of new biologics drug candidates. You actively contribute to projects at different stages, from early discovery up to regulatory submission stage. You develop and communicate experimental strategies, document results and build strong collaborations with the different stakeholders across pRED. You strive to maintain scientific excellence by developing innovative fit-for-purpose in vitro tools and approaches to address questions related to the disposition of biologics. You ensure that the best and most updated assays are implemented at Roche. Your profile You hold a PhD in cell/molecular biology or related relevant discipline with in-depth knowledge and several years of practical experience (preferably in industry) in the fields of cell-based models, cell and molecular biology, and quantitative methods to investigate protein transport. You are an expert in the use of different cellular models including primary cells, genome-edited or transgenic cell lines and microphysiological systems. You have broad knowledge in quantitative techniques such as FACS, ELISA and microscopy. Experience in high-throughput imaging and automated image analysis is desirable. You are familiar with common digital tools for experimental planning, FAIR data capturing, evaluation and reporting in databases and reports. You are committed to work in a team and are focused to drive the portfolio forward with the best approaches available. Your location The position will be located in Basel You’re someone who wants to influence your own development. You are looking for a company where you receive the opportunity to pursue your interests across functions and geographies. Working in a multi-cultural environment motivates you. Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche. Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be. We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. Job Level:Individual contributor This employer is a corporate member of myGwork - LGBTQ+ professionals, the business community for LGBTQ+ professionals, students, inclusive employers & anyone who believes in workplace equality.